Care este nivelul metale grele in apa de mare si care este toxicitatea lor?
Este o întrebare care necesita o abordare multipla. Sa luam ca exemplu arsenicul.
1) Exista o diferență biologica uriașă in asimilarea unui mineral organic fata de unul anorganic, si intre un mineral singular si unul in cuplajul lui natural in simbioza cu alte minerale sub forma ionica:
În apele de suprafață, arsenul anorganic este în principal sub formă de arsenaț.
In apele subterane arsenicul se găsește sub forma de arseniat (ATSDR, 2007).
In apa de mare si implicit in pești si moluște se găsește sub forma de arsenobetaina și arsenocholina, non-toxice in proporțiile sinergice naturale. (ATSDR, 2007).
2) Arsenicul există în mod normal în tiroidă, glanda mamară, oase, piele, păr. Acțiunea principală a arsenicului se exercită asupra proceselor de nutriție generală, diminuând arderile tisulare, favorizând asimilarea. Eliminarea arsenicului din alimentația animalelor a dus la afecțiuni ale aparatului reproducător și la limitarea creșterii acestora. Se consideră că arsenicul este implicat și în exprimarea informației genetice.” http://cesamancam.ro/arsenicul-alimente-otravire.html
3) Un exemplu edificator este comparația dintre cel mai vechi produs farmaceutic din apa de mare: Plasma Quinton. si cantitățile de arsenic admise in apele minerale si cele potabile.
Apele minerale conțin in general 0.7mg/L arsenic (sub forma organic ionica) si se găsesc in Romania la Covasna şi la Șarul Dornei. Sunt indicate în stări de debilitate, mai ales la copii, la convalescenți, în anemii secundare, disfuncții tiroidiene cu metabolism ridicat şi psoriazis. Administrarea se face cu cantități mici, de 25 ml, de două ori pe zi, până la 250 ml/zi. La sfârșitul curei cantitatea se micșorează treptat. (http://ziarullumina.ro/indicatiile-terapeutice-si-modul-de-administrare-a-apelor-minerale-49256.html)
Un mic calcul!
Daca se admite terapeutic 250 ml din aceasta ape minerale cu o cantitate de arsenic la 0.7mg/L, rezulta ca se ingerează zilnic aproximativ 0.2mg arsenic. Ori 0.2mg/L înseamnă 200ppb/L fata de 25 ppb cat conține Plasma Quinton. Dar 1L de Plasma Quinton nu se bea într-o zi, ci într-o luna (ptr 3 fiole pe zi) deci este vorba de o ingestie de 25ppb pe zi, care împărțita la 30 = 0.8 ppb pe zi.
(ptr calcul mg to ppb: http://www.endmemo.com/sconvert/mg_lppb.php)
Rezulta ca la trei fiole de Plasma Quinton pe zi suntem:
– de 12 ori sub limita admisa la arsenicul anorganic
– de 250 de ori mai puțin decât doza admisa in apele minerale terapeutice
Ca sa revenim la apa de mare, trebuie înțeles ca un produs ca Plasma Quinton este extras din zonele de vortex oceanic, cu cea mai mare concentrație de minerale organice, bio disponibile datorita tranzitării lor prin circuitul fito-zooplancton. Este firesc deci sa conțină toate urmele mineralelor existente, însă sub o forma sinergica care le potențează efectele benefice și le elimina pe cele toxice.
Faptul ca este acreditat si de WADA international, cel mai strict laborator de analize ptr sportivii de performanta, spune totul despre acest produs de excepție.
Cat despre studiile eficacității apei de mare in terapeutica, ele sunt numeroase si elocvente:
1.QUINTON, René. L’eau de Mer milieu organique (1912: Ed. Masson)
2.QUINTON, René & Dr. Robert SIMON. Seawater: injected subcutaneously in the treatment of pulmonary tuberculosis. Paris, Éditions de la Revue des Idées 1906
3.JARRICOT, Dr. Jean – Practice and Results of the Quinton Marine Method in Cases of Infantile Athrepsia and Cholera – Extrait de la „CURE MARINE” Revue Internationale de Thalassothérapie – année 1938, No. 1., Imp. Graphica, Rue des Pelletiers, 16, Bruges, Imprimé en Belgique
4. L’eau de mer en injections isotoniques sous cutanées dans le traitement de la Tuberculose Pulmonaire.
René Quinton et Dr Robert-Simon. 1906
5. L’eau de mer en ingestions pour les Dyspepsies.
Dr P. Barrère. 1907 . Allergothérapie spécifique et Thalassothérapie.
Dr Hervé de Lisle de LAUTURE.
6. Pratique et résultats de la methode marine de Quinton dans l’Athrepsie et le Choléra Infantile.
Dr J. Jarricot. 1938
7. DELALANDE Medical Research Center (France) under the directorship of Dr. B. Pourrias and Dr. G. Raynod. EXPERIMENT ON A DOG WITH OCEAN (Quinton) PLASMA DURING A STAGE OF HEMORRHAGIC SHOCK. May 1969
8.Nebulised hipertonic saline for cystic fibrosis. Wark PA, McDonald V. Cochrane Database Syst Rev. 2000
9. Cardiovascular protection of deep-seawater drinking water in high-fat/cholesterol fed hamsters.Chin-Lin Hsu, Yuan-Yen Chang, Chih-Hsien Chiu, Kuo-Tai Yang, Yu Wang, Shih-Guei Fu, Yi-Chen Chen, Food Chemistry 127 (2011) 1146–1152
10. Hypertonic saline in treatment of pulmonary disease in cystic fibrosis. Emer P. Reeves, KevinMolloy, Kerstin Pohl, and Noel G.McElvaney.
Scientific World Journal. 2012;2012:465230. doi: 10.1100/2012/465230. Epub 2012 May3.
11. Bio-Terrain, Evolutionary Biology, and the Practice of Medecine in the early 1900’s: An intro to René Quinton’s Marine Plasma
Roy Dittman, OMD, USA Explore! Volume 15, number 4 2006.
12. Female Reproductive Hygiene & Its Relationship to Human Fertility, Candida & STDs.
Roy Dittman, OMD, USA, Explore! Volume 17, November 4th 2008
13. Female Reproductive Hygiene Part II. Roy Dittman, OMD, USA/ Explore! 2008
14. Physiological Changes in Athletes as a Result of taking Microfiltered Sterilized Seawater [article in spanish/english]
Manuel Antonio Ballester Herrera/ VII Congreso de Setrade y XX Jornadas de Traumatología Deportiva; Valencia 2007
15. Physiological Changes in Athletes as a Result of taking Microfiltered Sterilized Seawater Part II
Manuel Antonio Ballester Herrera/ XXX FIMS World Congress of Sport Medicine; Barcelona 2008
16. Difference between deep seawater and surface seawater in the preventive effect of atherosclerosis
Miyamura M, Yoshioka S, Hamada A, Takuma D, Yokota J, Kusunose M, Kyotani S, Kawakita H, Odani K, Tsutsui Y, Nishioka Y.
Biol. Pharm. Bulletin 2004; 27(11): 1784-7
17 The role of trace minerals in osteoporosis. Saltman PD, Strause LG/ Journal American Collection Nutrition 1993 Aug; 12(4): 384-9
18. Spinal bone loss in postmenopausal women supplemented with calcium and trace minerals
Strause L, Saltman P, Smith KT, Bracker M, Andon MB/ Journal of Nutrition 1994 Jul; 124(7): 1060-4
19/ Irrigation with diluted seawater improves the nutritional value of cherry tomatoes./ Sgherri C, Kadlecová Z, Pardossi A, Navari-Izzo F, Izzo R
Journal of Agricultural and Food Chemestry 2008
20. Saline nasal irrigation, its role as an adjunct treatment./ Blake Papsin, Alison McTavish
Canadian Family Physician 2003; 49: 168-173
21. Establishing the possible immunomodulating activity of Quinton Isotonic Water through exvivo and invitro testing with murine splenocytes
Romero Montero F, Jimenez Valera M, Ruiz-Bravo López A/ Universidad de Granada
22. L’Hyponatrémie du sportif d’endurance.
Melin B, Jimenez C/ Cahiers de Nutrition et Diététique 2005
23. Pharmacological activity of deep seawater: examination of hyperlipemia prevention and medical treatment effect.
Yoshioka S, Hamada A, Cui T, Yokota J, Yamamoto S, Kusunose M, Miyamura M, Kyotani S, Kaneda R, Tsutsui Y, Odani K, Odani I, Nishioka
24. Biological and Phamaceutical Bulletin Volume 26 number 11 2003
Reduction of allergic skin responses and serum allergen-specific igE and IgE-inducting cytokines by drinking deep seawater in patients with allergic rhinitis/ Hajime K, Hideyuki T, Hirosho N / Otorhinolaryngologia Nova 2001;11:302-303
25. Improvement of skin symptoms and mineral imbalance by drinking deep sea water in patients with atopic eczema/dermatitis syndrome (AEDS)/ Kimata H, Tai H, Nakagawa K, Yokoyama Y, Nakajima H, Ikegami Y./ Acta Medica (Hradec Kralove). 2002;45(2):83-4.
26. Hypersaline nasal irrigation in children in symptomatic seasonal allergic rhinitis: a randomized study.
Garavello W, Romagnoli M, Sordo L, Gaini RM, Di Berardino C, Angrisano A./ Pediatric Allergy Immunol 2003: 14: 140-143
27. Efficacy of isotonic nasal wash (seawater) in the treatment and prevention of rhinitis in children
Slapak I, Skoupá J, Strnad P, Horník P./ Archives of Otolaryngology Volume 134, number 1 January 2008
28. Ausencia de genotoxicidad del agua de mar de Cobeñas: estudio invitro en eritrocitos y leucocitos humanos
Soler W, Velásquez NC, Miranda LF, Zuluaga DC/ Revista de la Facu Volumen 23 número 2 Julio-Diciembre 2005
29. Reduction of chemokine IL-8 and RANTES expression in human bronchial epithelial cells by a sea-water derived saline through inhibited nuclear factor-kappaB activation. Tabary O, Muselet C, Miesch MC, Yvin JC, Clément A, Jacquot J
Biochem Biophys Res Commun. 2003 Sep 19;309(2):310-6.
30. Heat-induced activation of reducing properties of seawater
Bruskov I, Chernikov AV, Gudkov SV, Masalimov ZhK./ Biofizika 2003 Nov-Dec; 48(6): 1022-9
31. Determination of Vitamin B1 in seawater and microalgal fermentation media by high-perfomance liquid chromatography with fluorescence detection/ Hong-Zhi, Hua-Bin Li, Feng Chen. Bioanal Chem (2005) 383:875-879
32. Drinking deep seawater restores mineral imbalance in athopic eczema/dermatitis syndrome. Hataguchy Y, Tai H, Nakajima H, Kimata H
European Journal of Clinical Nutrition (2005) 49, 1093-1096
33. Generation of Hydroxyl radicals and Other redox Active Compounds in the Seawater Exposed to Heat
Chermikov AV, Bruskov VI/ Biofizika 2002 Sept-Oct; 47 (5) : 773-81
34. Seawater or its Components Alter Experimental Irritant Dermatitis in Man/ Yoshizawa Y, Tanojo H, Kim SJ, Maibach HI.
Skin Research and Technology 2001; 7: 36-39
35. Treatment with Hypertonic Saline Versus Normal Saline Nasal wash of Pediatric Chronic Sinusitis.
Shoseyov D, Bibi H, Shai P, Shoseyov N, Shazberg G, Hurvitz H./ Journal Allergy Clinical Immunology 1998 May; 101(5): 602-5
36. The effect of seawater on expression of protease-activated receptor 2 in adenocarcinoma of lung cell line A549 cells.
Deng ZX, Qian GS, Yang Y, Zhou CX, Wang GS./ Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2009 Nov; 21(11): 648-51
37. Ensayos de Pirogenicidad
Jimenez Valera J/ Programa de Doctorado de Microbiología Universidad Granada 2002-2003
38. Efficiency of hypertonic and isotonic seawater solutions in chronic rhinosinusitis.
Culig J, Leppée M, Vceva A, Djanic D./ Med Glas Ljek komore Zenicko-doboj kantona 2010 Aug; 7(2): 116-23
39. Intake of dissolved organic matter from deep seawater inhibits atherosclerosis progression.
Radhakrishnan G, Yamamoto M, Maeda H, Nakagawa A, KatareGopalrao R, Okada H, Nishimori H, Wariishi S, Toda E, Ogawa H, Sasaguri S.
Biochemical and Biophysical Research Communications 387 (2009) 25–30
40. Pharmacological activity of deep-sea water: examination of hyperlipemia prevention and medical treatment effect.
Yoshioka S, Hamada A, Cui T, Yokota J, Yamamoto S, Kusunose M, Miyamura M, Kyotani S, Kaneda R, Tsutsui Y, Odani K, Odani I, Nishioka Y. Biol. Pharm. Bulletin 26(11) 1552—1559 (2003)
41. Inhibitory effect of deep-sea water on differentiation of 3T3-L1 adipocytes. Hwang HS, Kim SH, Yoo YG, Chu YS, Shon YH, Nam KS, Yun JW. / Mar Biotechnol (2009) 11:161–168 DOI 10.1007/s10126-008-9131-8
42. Anti-obesity and antidiabetic effects of deep sea water on ob/ob mice.
Hee Sun Hwan, Hyun Ah Kim, Sung Hak Lee, Jong Won Yun
Mar Biotechnol (2009) 11:531–539 DOI 10.1007/s10126-008-9171-0
43. Immunomodulatory Activities of Quinton’s Isotonic and Hypertonic Solution Part I.
Sempere JM/ European Congress of Immunology Berlin 2009
44. Immunomodulatory Activities of Quinton’s Isotonic and Hypertonic Solution Part II
Sempere JM/ International Congress of Immunology Tokyo 2010
45. Immunomodulatory Activities of Quinton’s Isotonic and Hypertonic Solution Part III in Rheumatoid Arthritis and Systemic Lupus Erythematosus/ Sempere JM. Biotechnoly Department of the University of Alicante 2010
46. Marine Therapy and its Healing Properties
Coll F/ Fith Stromboly Conferences on Aging and Cancer 2010; pag 19
47. Mineral-enriched deep-sea water inhibits the metastatic potential of human breast cancer celllines
Kim S, Chun SY, Lee DH, Lee KS, Nam KS./ International Journal Of Oncology 43: 1691-1700, 2013
48. Study of the Effect of Quinton Hypertonic on Blood Pressure when it is Taken Daily
Alberola J, Pellin M, Sempere JM/ Bulletin Informa Quinton 2012
49. Trace minerale status in post menopausal women: impact of hormonal replacement therapy.Bureau I, Anderson RA, Arnaud J, Raysiguier Y, Favier AE, Roussel AM/ Journal Trace Elements Med BIo 2002; 16(1) 9-13
50. Utilización del Agua de Mar como Agente Regulador de Peso en Niños con Bajo Peso para su Edad
Jimenez J/ Jornadas Nacionales de Alimentación; Huelva 2006
51. Utilización del Agua de Mar como Agente Reductor de la Inflamación de Eccemas
Jimenez J/ Congreso Nacional de Farmacéuticos; Cádiz 2006
52. Use of Seawater in Milk Diet Babies Eczema
Ortiz B, Santandreu MJ/ XXVII Symposium of The International Society of Dermatology; Malaga 2006
53. Marine Therapy and Its Healing Properties.
Coll F/ Water Conferences; Bulgaria 2013
54. Acceptance and effects of nasal lavage in volunteer woodworkers.
Rabone SJ, Saraswati SB./ Occup Med (Lond). 1999 Aug;49(6):365-9.
55. Hypertonic saline decreases ciliary movement in human nasal epithelium in vitro.
Min YG, Lee KS, Yun JB, Rhee CS, Rhyoo C, Koh YY, Yi WJ, Park KS.
Otolaryngol Head Neck Surg. 2001 Mar;124(3):313-6.
56. Drinking deep seawater decreases serum total and low-density lipoprotein-cholesterol in hypercholesterolemic subjects.
Fu ZY, Yang FL, Hsu HW, Lu YF.
J Med Food. 2012 Jun;15(6):535-41. doi: 10.1089/jmf.2011.2007. Epub 2012 Mar 16.
57. Necessità di un corretto equilibrio idroelettrolitico nell’anziano con demenza: Il Plasma Marino.
Lacava R.*[1], Castagna A.[2], Aversa A.[3], Cotroneo A.M.[4], Mazzei F.[5], Pontieri M.T.[5], Costantino D.S.[1], Gareri P.[1].
58° Congresso Nazionale sigg – Comunicazioni Orali e Poster
58. Study of the potential geroprotector “Quinton Marine Plasma experiments” in cultured cells.
Хохлов А.Н., Клебанов А.А., Рындина Т.С., Насонов М.М., Coll F.
http://istina.msu.ru/publications/article/4700446/
59.On the influence of potential geroprotector “Quinton Marine Plasma “on the viability of cultured cells of Chinese.
Рындина Т.С., Coll F., Хохлов А.Н.
http://istina.msu.ru/publications/article/2121440/
60 .Buche, N.D., Juergen. Seawater. 2006
61 . Deep Sea Water modulates blood pressure and exhibits hypolipidemic effects via the AMPK-ACC pathway: an in vivo study.
Ming-Jyh Sheu 1,*, Pei-Yu Chou 2, Wen-Hsin Lin 1, Chun-Hsu Pan 1, Yi-Chung Chien 1, Yun-Lung Chung 1, Fon-Chang Liu 1,3 and Chieh-Hsi Wu 1,*Mar. Drugs 2013, 11, 2183-2202; doi:10.3390/md11062183
62 . Marine Therapy and its healing properties.Alberola J, Coll F, Current Aging Science 2013, 6, 63-75